Prompt
A structure-function figure of the TREM2 R47H variant: wild-type receptor binding its lipidated ligand snugly versus the R47H substitution weakening the binding pocket, with downstream signaling arrows thinning and clearance dropping on a small bar inset. Label "WILD TYPE", "R47H", "BINDING POCKET", "SIGNALING". Title: "ONE LETTER, LESS CLEARANCE".. Workflow direction: Create one publication-quality science-communication illustration in a single generation. It must demonstrate both visual craft and explanatory power: a compelling central subject, a clear reading order, multiple meaningful layers of information, and a polished editorial composition that still reads at thumbnail size.
Follow the user's requested entities, relationships, sequence, viewpoint, audience, and quoted text exactly. Pick the figure grammar that best serves the topic and state it through the rendering itself: anatomy or specimen plate, cutaway or cross-section, molecular or signaling mechanism, step-by-step process or workflow, side-by-side comparison, system or network architecture, chart or plot, instrument diagram, or narrative scene. Match the rendering technique to that grammar — flat clean vector for flows and architecture, dimensional molecular rendering for micro structures, semi-realistic tissue or material rendering for cutaways, cinematic depth only for scenes — instead of forcing every topic into one house style.
Default canvas is a clean white or near-white field like a journal figure: no decorative frame, plate border, aged paper texture, or faux page furniture unless the user explicitly asks for them. Label the figure the way a journal would: direct horizontal text joined to its structure by a thin non-crossing leader line. Switch to numbered markers with a compact key only when the subject is too dense for direct labels, and include a legend only when color or symbols encode meaning. One short title, 4–8 essential labels, purposeful arrows for real movement, sequence, reaction, or causal flow with consistent arrow grammar, and at most one magnified inset that adds genuine understanding.
Render requested English or Chinese text as sharp, horizontal, high-contrast, correctly spelled text; never paraphrase quoted labels or leak prompt instructions into the artwork. Reserve a generous 10–15% outer safe area on all four sides; every title, label, leader line, legend and inset must be fully visible inside that safe area, never touching or crossing the canvas edge. Prefer fewer complete labels over cropped or microscopic copy.
Scientific accuracy outranks decoration. Preserve topology, orientation, relative position, sequence, direction and scale cues; never invent anatomy, structures, measurements, provenance, causal relationships or pseudo-data. When literal scale cannot fit, visibly signal a schematic or not-to-scale treatment. The result must be self-contained and credible as a figure a researcher could paste into a manuscript, thesis, grant, poster, textbook, classroom explainer, or public-science article.
Style-specific direction:
Style: modern clinical illustration — crisp semi-realistic tissue rendering with controlled depth on a clean white field, like a publication-ready patient-education or medical-school figure. Shift to a premium printed-atlas plate look only when the user asks for it.
Subject conventions: honor the requested anatomical plane, laterality, tissue layers, spatial relationships, and clinically standard orientation.
Composition: isolate the relevant region but show enough surrounding anatomy to establish orientation; add one sectional or magnified inset when it clarifies tissue continuity, flow, or mechanism.
Color: restrained conventional tissue colors with consistent color coding across the figure.
Label convention: direct leader-line labels with accepted anatomical terms, anchored to the correct tissue or landmark.
Avoid: diagnostic claims, surgical recommendations, gore, decorative anatomy, and impossible tissue co
